In vitro cytotoxic, antiprotozoal and antimicrobial activities of medicinal plants from Vanuatu
Identifieur interne : 001713 ( Main/Exploration ); précédent : 001712; suivant : 001714In vitro cytotoxic, antiprotozoal and antimicrobial activities of medicinal plants from Vanuatu
Auteurs : Gesine Bradacs [Allemagne] ; Louis Maes [Belgique] ; Jörg Heilmann [Allemagne]Source :
- Phytotherapy Research [ 0951-418X ] ; 2010-06.
English descriptors
- Teeft :
- Acalypha, Acalypha grandis benth, Allophylus timoriensis, Ambrym, Americanus, Aneityum, Antimalarial activity, Antimicrobial, Antimicrobial assays, Antiprotozoal, Antiprotozoal assays, Arborescens, Assay, Baccaurea, Baccaurea stylaris, Baccaurea stylaris muell, Bijuga, Brucei, Cell lines, Cell viability, Control wells, Copyright, Cytotoxic, Cytotoxic effects, Cytotoxicity, Dichloromethane, Dichloromethane extracts, Dioica, Dmso, Dysoxylum, Dysoxylum arborescens, Dysoxylum kuskusense, Ethyl acetate, Ethyl acetate extracts, Euodia latifolia, Extract, Falciparum, Grandis, Gyrocarpus, Gyrocarpus americanus, Gyrocarpus americanus jacq, Human cancer cell lines, Infectious diseases, Inner bark, Intsia, Intsia bijuga, John wiley sons, Macaranga, Macaranga dioica muell, Macropiper latifolium, Maximum concentration, Medicinal, Medicinal plants, Methanolic, Microtiter, Microtiter plates, Muell, Natural products, Other members, Pandacaqui, Parasite, Penicillin, Pharmacological activities, Phytother, Plant part, Plasmodium falciparum, Reference drug, Sodium bicarbonate, Standard deviation, Streptomycin, Strong cytotoxic effects, Stylaris, Tabernaemontana, Tabernaemontana pandacaqui, Traditional medicine, Trypanosoma, Trypanosoma cruzi, Vanuatu, Zingiber zerumbet.
Abstract
Sixty‐three extracts obtained from 18 plants traditionally used in the South Pacific archipelago Vanuatu for the treatment of infectious diseases were screened for antimicrobial and antiprotozoal activities. In addition, the extracts were subjected to a detailed analysis on cytotoxic effects toward a panel of human cancer cell lines, designed as a smaller version of the NCI60 screen. Intriguingly, 15 plant extracts exhibited strong cytotoxic effects specific for only one cancer cell line. Extracts of the leaves of Acalypha grandis Benth. significantly affected Plasmodium falciparum without showing obvious effects against the other protozoa tested. The leaves of Gyrocarpus americanus Jacq. displayed significant activity against Trypanosoma b. brucei and the leaves of Tabernaemontana pandacaqui Lam. I as well as the stems of Macropiper latifolium (L.f.) against Trypanosoma cruzi. In contrast none of the extracts showed relevant antibacterial or antifungal activity. Copyright © 2009 John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/ptr.2981
Affiliations:
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In addition, the extracts were subjected to a detailed analysis on cytotoxic effects toward a panel of human cancer cell lines, designed as a smaller version of the NCI60 screen. Intriguingly, 15 plant extracts exhibited strong cytotoxic effects specific for only one cancer cell line. Extracts of the leaves of Acalypha grandis Benth. significantly affected Plasmodium falciparum without showing obvious effects against the other protozoa tested. The leaves of Gyrocarpus americanus Jacq. displayed significant activity against Trypanosoma b. brucei and the leaves of Tabernaemontana pandacaqui Lam. I as well as the stems of Macropiper latifolium (L.f.) against Trypanosoma cruzi. In contrast none of the extracts showed relevant antibacterial or antifungal activity. 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